Roles of the HIF-1α pathway in the development and progression of keloids

Keloids, a pathological scar that is induced by the consequence of aberrant wound healing, still major global health concern for its unsatisfactory treatment outcomes. HIF-1α, main regulator hypoxia, mainly acts through some proteins or signaling pathways and plays important roles in variety biological processes. Accumulating evidence has shown HIF-1α played crucial role process keloid formation. In this review, we attempted to summarize current knowledge on association between expression development progression keloids. Through comprehensive analysis, molecular mechanisms underlying keloids were be correlated proliferation fibroblasts, angiogenesis, collagen deposits. The affected multiple. For instance, was reported promote formation enhancing fibroblast proliferation, deposition activation periostin PI3K/Akt, TGF‐β/Smad TLR4/MyD88/NF-κB pathway. However, specific effects illnesses clinical practice are entirely unclear, further studies trials warranted. Therefore, an in-depth understanding significant develop promising therapeutic targets practice.